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In adults, neurologic symptoms of biotin deficiency include depression, lethargy, hallucinations, and numbness and tingling of the extremities (35)

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Moreover, studies have stressed on the importance of molecular glue degraders as a remedy for neurodegenerative diseases, 556 though their broad-scale implementation requires pervasive research efforts in the fields of molecular biology and medicinal chemistry

By age 90, melatonin levels drop below 20% of young adult concentrations

Acknowledgements The authors are grateful for the support of NIH, to Lisa Howerton for her administrative support, and to the study participants and their families of the Mayo Pharmacogenomics Research Network-Antidepressant Pharmacogenomics Medication Study (PGRN-AMPS)