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Results: Meta-analysis showed a statistically significant effect of curcumin on depressive symptoms (SMD: 0.65, P = 0.01, 95% CI: 1.16 to 0.13, I 2 = 93%) and anxiety symptoms (SMD: 0.22, P = 0.01, 95% CI: 0.40 to 0.05, I 2 = 0%)

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This effect was fully suppressed by the microglial inhibitor minocycline and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, underscoring the essential role of microglial activation and the p38 MAPK pathway [72]

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