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Functional mechanotransduction is a known requirement for aminoglycoside entry into hair cells and its resulting ototoxicity (Alharazneh et al., HGF/c-Met activates a diverse set of signal transducers capable of inhibiting cell death

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But as large cardiovascular outcome trials accumulated, it became clear these drugs were doing far more than managing glucose

In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, males were treated for 4 weeks prior to mating, during mating, up to scheduled termination (approximately 8 weeks total) and females were treated 2 weeks prior to mating through gestation day 7