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This gradual titration helps minimise gastrointestinal side effects such as nausea, vomiting, and diarrhoea

At validated doses, GLP-1 therapy commonly reduces HbA1c by roughly 1.01.5 percentage points in clinical trials

Studies showing meaningful effects generally used 1,000mg or more per day

Off-label prescribing accounts for roughly 20% of all prescriptions written in the United States