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Whilst B12 has a low risk of toxicity even at high doses, it is prudent to consider whether such high intake is necessary unless advised by a healthcare professional

Food and Drug Administration or any equivalent regulator for human therapeutic use, and controlled efficacy trials in humans for the indications most often associated with the peptide tendon, ligament, and connective tissue injury have not been completed or published in the peer-reviewed literature

Take an alcohol prep pad and vigorously wipe the top of each rubber stopper

Just keep in mind, we need more research to prove the exact link between B12 and headaches or migraine