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As the medical field evolves, we are hopeful that targeted metabolic therapies may one day complement surgical care or offer new avenues for those who cannot pursue surgery

Results showed that liraglutide treatment significantly reduced ( p = 0.0286) IL-1-induced expression of Adamts4 , Adamts5 , Mmp-3 , and Mmp-13 in a dose-dependent manner compared with the IL-1 group (Fig

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Its HDAC inhibitory activity directly contributes to the reactivation of silenced tumor suppressor genes and is a key mechanism underlying its remarkable anti-tumor effects in urologic and other cancers, as observed both in vitro and in vivo without significant toxicity ( 4.2 Ferroptosis induction: an emerging cell death mechanism Beyond its established roles in apoptosis and cell cycle arrest, SFN demonstrates significant capacity to induce ferroptosisan iron-dependent form of regulated cell death characterized by lethal lipid peroxide accumulation

In conducting this review, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure rigorous methodology and transparent presentation of data