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1 At high concentrations K m ) m max Clinical Implications of Michaelis-Menten Kinetics Drugs that have a therapeutic range that falls on the steep, transitional part of the Michaelis-Menten curve are said to have a narrow therapeutic index and pose significant clinical challenges

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Murdocca M, De Masi C, Pucci S, Mango R, Novelli G, Di Natale C et al (2021) LOX-1 and cancer, an indissoluble liaison