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But the biggest surprise came when the dose was increased from 1 mg to 2.4 mg per week: not only was blood glucose control excellent, but weight loss was astounding obese people without diabetes lost on average 15% of their starting weight (more than 30 pounds in a person starting at 220 pounds)

He has also explained the motivation behind the change in very Barkley fashion

Furthermore, liraglutide treatment for 10 days in obese T2DM patients attenuated insula and putamen fMRI responses to food pictures in fasted and post-meal conditions, compared with insulin glargine injection [42]

People skip breakfast, pick at lunch, then try to make up for it with a large evening meal

Pathways linking BMI trajectories and mental health in an adult population-based cohort: role of emotional eating and body dissatisfaction