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Chesselet MF, Carmichael ST

Now I control food." Normalize Satiety Signaling Many patients with insulin resistance have disrupted hunger hormones (leptin, ghrelin, PYY)

Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB

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Side effects with Wegovy 7.2 mg The STEP UP trial found that side effects were somewhat more common at the higher dose: 2 GI side effects: 70.8% (7.2 mg) vs 61.2% (2.4 mg) Dysaesthesia (tingling/numbness): 22.9% (7.2 mg) vs 6.0% (2.4 mg) Discontinuation due to side effects remained low at 3.3% The dysaesthesia finding is notable, though 85.7% of cases resolved while continuing treatment