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Significant reductions in serum levels of total IS, p-CS, IL-6, and malondialdehyde (as markers of inflammation and oxidative stress, respectively) were observed in 30 patients with ESKD undergoing hemodialysis treatment after an 8-week administration of synbiotics containing 2 10 11 (CFU)/g of Lactobacillus acidophilus La-14 and FOS (Kuskunov et al., 2023)

Akkermansia muciniphila is uniquely positioned within this network, acting not as a direct hormone producer but as an ecosystem regulator

Some studies suggest potential benefits, while others raise concerns about efficacy and safety

Diabetes 63(2):785790

2023;381:e074068