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Abbreviations AG1478 4-(-3-chloroanilino)-6,7-dimethoxyquinozoline TPN Total parenteral nutrition IBD inflammatory bowel disease ERK Extracellular signal-regulated kinase MAPK Mitogen-activated protein kinase EGF epidermal growth factor EGFR EGF receptor PI3K Phosphatidylinositol 3-kinase TER transepithelial electrical resistance ZO-1, ZO-2 & ZO-3 zona occludens-1, -2 & -3 GSH glutathione REFERENCES 1.Lacey JM, Wilmore DW

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This hormonal response can contribute to weight gain, increased insulin resistance, and difficulty maintaining stable metabolic function