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The FDA label (NDA 021446) lists the following key pharmacokinetic parameters: oral bioavailability greater than 90%, linear pharmacokinetics up to 600 mg/day, renal elimination as unchanged drug (greater than 98%), and no meaningful hepatic CYP metabolism [4]

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Total renal and aortic Gstm1 expression in transgenic animals was significantly increased compared with SHRSP [renal relative quantification (RQ): SHRSP-Tg(Gstm1)1WKY 1.95 vs

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