Tirzepatide is a synthetic peptide belonging to the class of dual incretin receptor agonists, designed to interact with both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor [1]
Add psoriatic arthritis I'd love to see evidence that separates the effect GLP1 has in reducing intake of harmful substances (UPF, smoking, alcohol) which we know drive these long term conditions, versus direct effects of the drug
Sustainable Results: Tirzepatide has demonstrated long-lasting effects, helping individuals maintain their weight loss over time
GLP-1 is a hormone that is naturally involved in appetite regulation, insulin release, and digestion
The Saxagliptin Assessment of Vascular Outcomes (SAVOR-TIMI 53) study is a similar study in 12,000 patients comparing saxagliptin with placebo in diabetic patients with high cardiovascular risk