Additionally, discrepancies in findings from other LC supplementation meta-analyses may be attributed to differences in population characteristics, types of interventions, sample sizes, study quality, and measurement methods, complicating the assessment of LCs effects across different patient groups
This interaction site is less defined but comprises the glutathione moiety of Grx(SSG), parts of helix 3, and a conserved lysine/arginine residue that also contributes to the scaffold site 14,15
A 48-week Phase 2 trial reported in The Lancet in 2025 showed mean weight reduction ranging from approximately 9% at the lowest dose to 20% at the highest dose, compared with 0.4% on placebo
Heinla K, Vasar E, Sedman T, Volke V
Reddy IA, Stanwood GD, Galli A