This is compared to NMDA EPSCs that experienced no significant changes in amplitude when IGF-1 DES was administered [2]
Semaglutide has been undetectable in human milk samples, and NIH LactMed reports tirzepatide is usually undetectable at doses up to 5 mg, suggesting potential infant exposure is low based on limited data., What is known vs unknown about GLP-1 medications in breast milk Known: Semaglutide has been undetectable in small human milk studies Tirzepatide is usually undetectable in limited LactMed summaries GLP-1 medications are large peptide molecules with poor oral absorption Unknown: Long-term infant health or developmental outcomes Effects on milk supply or milk composition Safety in newborn or preterm infants Scientific explanation peptide size and oral bioavailability GLP-1 receptor agonists are large peptide molecules with high molecular weight, which limits their ability to diffuse from maternal blood into breast milk. In addition, peptide drugs have poor oral bioavailability, meaning that even if small amounts are ingested, systemic absorption by the infant is unlikely., Plain-English explanation why the babys stomach offers protection GLP-1 medications are peptide-based and must be injected because the stomach destroys them
Cell (2012) 148(12):24458
Every day, it's bombarded by things that damage it: UV radiation from the sun, pollution, stress, poor sleep, alcohol, and the natural metabolic processes your body runs just to keep you alive
You can also contact Novo Nordisk (the manufacturer) directly with product quality concerns
