tirzepatide surpass 4 Effects of versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial Tirzepatide reduces albuminuria among adults

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Li X, Wang Z, Ma Q, Xu Q, Liu H, Duan W, et al

Together, these data indicate that MOTS-c treatment can improve overall physical performance, in part, by targeting skeletal muscle metabolism in young mice

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Clinical trial data from the SURMOUNT-1 sub-study showed an average total lean mass loss of 10.9% [4] over the course of the study, and data from the STEP-1 semaglutide study showed a 10% total reduction in skeletal muscle mass [5]