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The combined 8mg groups in the trial lost 22.8% of body weight at 48 weeks, with 100% of participants achieving at least 5% weight loss and 91% achieving 10% or more

Published studies suggest the magnitude of effect in obesity cohorts may be larger with triple agonism at top doses, though head-to-head laboratory comparisons are still emerging in the published record

3.2 Gut-brain axis The acquisition of gut microbiota begins at birth, and by the age of 1236 months, infant microbiota profiles resemble those of adults (101103)