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Overexpression of P-gp in cancerous cells is a principal factor contributing to MDR against anti-cancer drugs like doxorubicin (DOX), etoposide, olaparib, paclitaxel, and vinblastine, amongst others [35, 39,40,41,42,43]

1 It has been established that melatonin stimulates GPx in vivo , enhancing GPx activity, during which H 2 O 2 is metabolized to H 2 O, and glutathione (GSH) is oxidized to its disulfide form GSSG (Fig

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The effects of habitual resistance exercise training on cerebrovascular responses to lower body dynamic resistance exercise: a cross-sectional study