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Whilst the Medicines and Healthcare products Regulatory Agency (MHRA) approved Wegovy based on robust clinical trial data, patients may experience various side effects during treatment, with fatigue being a recognised concern

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It also suppresses ABCA1 via the Nrf2/ABCA1 pathway, reducing cholesterol efflux and promoting macrophage foam cell lipid accumulation (Makrecka-Kuka et al., 2017)