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The ROSs immediately react with polyunsaturated fatty acids in membranes, form reactive aldehydes and further deplete cellular stores of glutathione, leading to disruption of membrane structure

Klasen, Claudia Cavelti-Weder, and Tarik Delko have no conflicts of interest or financial ties to disclose

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The consumption of alcohol is significantly reduced, but only in genetically-determined alcohol-preferring rats or those selected from an outbred population for high-alcohol consumption

A final grade of low risk of bias, some concerns of bias and high risk of bias was attributed to each article considering the score in each section