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We enriched ER36 + and ER36 subpopulations, respectively, from MCF-7 and MDA-MB 436 cell lines (Supplementary information, Figure S3A-C), and found 17-estradiol (E2) similarly stimulated proliferation of both cell populations (Figure 3A and Supplementary information, Figure S3D)

It does this by activating the GH axis, which leads to a downstream increase in systemic growth hormone levels

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(2023, April 15)