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By engaging these systems, Melanotan 2 may alter the functional connectivity of cortical and subcortical networksregions including, for instance, the anterior cingulate cortexwhere oxytocin receptor distribution may differ in atypical neurodevelopmental contexts

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Recently, neural activity mediated by NMDA-receptors (NMDAR) has been coupled with transcriptional activation of glutamate-cysteine ligase, a key enzyme in GSH production, leading to a sustained GSH-based protection against an oxidative insult 26