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Boehringer Ingelheim announced positive Phase III results for survodutide, a glucagon/GLP-1 dual agonist, showing weight loss and metabolic improvement in obesity and overweight populations, while also building evidence in MASLD-related metabolic disease
Given the rich lipid content of the nervous system, hemoglobin-derived iron works with lipid peroxidation to induce ferroptosis, which eventually leads to neuronal mitochondrial damage, edema, and apoptosis of neurons and astrocytes
Nucleic Acids Res 37, D933D937, doi: 10.1093/nar/gkn823 (2009)