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[24] In 2020, the FDA approved two higher doses of the medication, 3.0 mg and 4.5 mg, based on results of the AWARD-11 trial demonstrating improved glucose lowering and weight benefits

In real-world practice, patients who experience severe gastrointestinal side effects may adjust their behavior more freely, drinking more fluids, reducing doses, or taking breaks

One study found that combining MSM with glucosamine and chondroitin was more effective at decreasing pain and stiffness in people with knee osteoarthritis than glucosamine and chondroitin alone ( Another study showed that a daily supplement containing 5 grams of MSM and 7 grams of boswellic acid was more effective than glucosamine at reducing pain and improving function in people with knee osteoarthritis ( Whats more, the people who received the MSM and boswellic acid supplement were less dependent on anti-inflammatory medications than the glucosamine group ( Summary MSM supplements have been shown to help reduce pain and stiffness in people with arthritis

JACC Basic Transl Sci 3(6):844857