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The regulatory elements within the ARE sequences of these genes confer specificity to the NRF2 transcriptional signature, which varies according to cell type, intensity, and duration of the stimuli (Lee et al

Interestingly, BSO treatment did not affect SLC25A39 mRNA levels (Extended Data Fig 1c), but could induce SLC25A39 protein accumulation when an SLC25A39 cDNA lacking UTR elements was expressed ectopically under a viral promoter (Extended Data Fig 1d), thereby suggesting regulation at the post-translational level

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The mechanisms underlying these effects are UA-induced oxidative stress and inflammation within the -cells

Steinmann, P., Keiser, J., Bos, R., Tanner, M