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Further population-based studies may quantify incidence rates, characterize dose-dependent relationships, and investigate mechanistic pathways to optimize risk stratification and therapeutic decision-making

Tirzepatide, the GLP-1 in Zepbound and Mounjaro, pushed Eli Lilly past US$1 trillion in market capitalization on November 21, 2025 the first healthcare company in history to cross that threshold

This study was primarily funded by Brassica Protection Products LLC, Baltimore, MD

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Editors note: An earlier version of this article included a photo of boxes of the drug Mounjaro and incorrectly described them in a caption as semaglutide injection pens