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Because the amino acid cysteine is a substrate for the rate-limiting step in the production of glutathione, it's important to make sure you're getting enough through diet and/or NAC supplementation

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This dependence on G6PD activity in activated T cells occurs despite the partially redundant contribution of other enzymes like isocitrate dehydrogenase and malate dehydrogenase to the overall production of cellular NADPH, which is needed for biosynthesis of immune effector molecules ( Figure 1A-3 )

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All adverse event data in this article comes from two sources: the Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023) and the TRIUMPH Phase 3 program data presented at medical conferences

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General Discomfort : A nonspecific sense of discomfort or unease throughout the body

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[PMC free article: PMC4189962] [PubMed: 24576947] 774

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