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Tiredness: Drink plenty of fluids and electrolytes and eat a balanced diet with an increased frequency of meals

The supply-chain integrity is the rate-limiter

Unveiling the Benefits 1

Integration Produces Measurably Greater Outcomes The first principle is that combining these therapies appears to produce results that neither achieves alone

Populations Inclusion and Exclusion Criteria All studies except STEP 2 included patients with a BMI of 30.0 kg/ m 2 or greater, or 27.0 kg/m 2 or greater with the presence of at least 1 of the following weight-related comorbidities (treated or untreated): hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease (Table 6, Table 8, Table 9, and Table 10)