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Research suggests that concerns are more closely linked to factors such as reduced fluid intake, digestive side effects, and dehydration rather than a direct effect of the medication on the kidneys

Strain WD, Frenkel O, James MA, et al

These proteins included extracellular vesicle interleukin-2 (EV IL2) and cathelicidin antimicrobial protein (CAMP) which were elevated, while immunoglobulin lambda variable 1-47 (IGLV1-47), cartilage acidic protein 1 (CRTAC1), leucine-rich alpha-2-glycoprotein 1 (LRG1), insulin-like growth factor 1 (IGF1), and tubulin alpha-1 (TUBA1) were decreased relative to healthy controls