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Because progressive loss of -cell insulin secretory capacity is associated with worsening hyperglycemia, targeting intrinsic -cell activity is considered essential in T2D management

An interlock that prevents discharge when the enclosure is open reduces human error

These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects

Allan, C

Stroke and Excitotoxicity Protection Excitotoxicity protection appeared in stroke models where bilateral carotid artery clamping produces ischemia-reperfusion injury with massive glutamate release