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For example, in HGC-27 cells, lactylation of METTL16 at lysine 229 promotes cuproptosis via m 6 A modification of the mRNA of ferredoxin 1 (FDX1), a key factor encoding a reductase known to convert Cu 2+ to its more toxic form Cu 1+ , indicating the promising therapeutic potential of targeting Kla and cuproptosis in cancer

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Notably, 13 genes and their corresponding proteins were upregulated in group H-IMF, including LCN2 (Lipocalin 2), MPO (Myeloperoxidase), CATHL4 (Cathelicidin 4), ACAN (Aggrecan), TTN (Titin), CATHL3 (Cathelicidin 3), CHAD (Chondroadherin), PGLYRP1 (Peptidoglycan Recognition Protein 1), AZU1 (Azurocidin 1), COL2A1 (Collagen Type II Alpha 1 Chain), PRG3 (Proteoglycan 3), and NGP (Neutrophilic Granule Protein)

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