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Risks of Concomitant Use or Discontinuation of Cytochrome P450 3A4 Inhibitors and Inducers Concomitant use of Oxycodone and Acetaminophen Tablets with a CYP3A4 inhibitor, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir), may increase plasma concentrations of oxycodone hydrochloride and prolong opioid adverse reactions, which may cause potentially fatal respiratory depression [seeWARNINGS], particularly when an inhibitor is added after a stable dose of Oxycodone and Acetaminophen Tablets is achieved

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Quite interestingly, the beneficial health effects of DHA and EPA on metabolic diseases are thought to arise from their binding to and activation of PPARs (107), as it was shown illustratively for T1D in Table 2

Antioxidants (Basel) 13, 120

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