These findings informed human PET studies using the HDAC tracer [11C] Martinostat, which confirmed elevated HDAC expression in the brains of chronic drinkers
This metabolic switching is regulated by sirtuins, namely SIRT3 and SIRT2 repress the Warburg effect 342,343,344,345 , while SIRT5 maintains glycolysis 346
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This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 265,23 per year only 22,10 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References McMurray, J