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Early-phase clinical trial data, including results from a Phase 2 trial published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023), demonstrated substantial weight reduction in participants receiving retatrutide with some individuals losing more than 20% of their body weight over 48 weeks

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Comment: Several commenters stated that although they appreciated the 4-year pricing transition for the SA051 pelvic exam pack, they remained concerned that even a phased-in reduction will materially decrease practice expense RVUs for a broad range of services furnished by gynecologists