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In addition, after ischemia-reperfusion injury, the expression of proinflammatory cytokines, NF- B and ICAM-1, as well as macrophage infiltration in the kidney was significantly decreased by exendin-4 (10 g/kg) or sitagliptin (600 mg/kg) treatment [109]

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(September 2025)

Safety Monitoring and Who Should Consider This Approach GLP-1 compounds are generally well-tolerated for triglyceride management in adults without contraindications to GLP-1 therapy (active pancreatitis history, personal medullary thyroid carcinoma, or MEN-2 syndrome)