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Hempstock W, Nagata N, Ishizuka N, Hayashi H

The role of extracellular vesicles and interleukin-8 in regulating and mediating neutrophil-dependent cancer drug resistance

4) Underexplored therapeutic strategies and model limitations: Preclinical studies have relied heavily on lupus-prone mouse models (e.g., MRL/lpr mice), which may not fully recapitulate human LNs complexity (e.g., genetic heterogeneity, variable disease progression, and response to therapy)