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Often brought on by extensive sun exposure and damage, pregnancy, hormone treatments, and hyperthyroidism, melasma is seen most often in women aged 20 to 40.Although it can occur in individuals of any nationality, this condition is most likely to affect Fitzpatrick skin types 3 and 4, or skin with a naturally-tanned appearance as seen in the Middle East and Asia

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GHK-Cu Peptide Regulatory Status in Canada Health Canada Regulatory Status - Cosmetic Ingredient Framework Synthetic GHK-Cu is permitted as a cosmetic ingredient under the INCI name 'Copper Tripeptide-1' and appears in topically-applied cosmetic products in Canada and internationally under the Food and Drugs Act and the Cosmetic Regulations