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Liver slices from mice exhibited marked liver injury when incubated with acetaminophen, which was accompanied by extensive metabolism of the drug and by glutathione conjugate formation (demonstrating that metabolic bioactivation had occurred), while mouse liver slices that were incubated with equivalent doses of AMAP exhibited a markedly reduced extent of injury and did not generate detectable levels of glutathione conjugates
Int Clin Psychopharmacol 16:8792 Bilici M, Ozturk C, Dursun H, Albayrak F, Saglam MB, Uyanik A, Gulaboglu M, Tekin SB (2009) Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters
Antioxidants, August 2021, ePublication 2
However, In Colombia only some determinations have taken place in small groups (data without publishing), and there exist small work groups from certain universities like the Universidad del Rosario of Bogotas, who will soon give their results in relation to the prevalence of this alteration in the metabolism of hereditary type