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Davies said several GLP-1/glucagon dual agonists have moved on to phase 2 or phase 3 trials, including survodutide (Boehringer Ingelheim), efinopegdutide (Hanmi Pharmaceutical), mazdutide (Eli Lilly and Innovent) and pemvidutide (Altimmune)

0.838 0.097, P = 0.19)

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95,96 Excessive endoplasmic reticulum stress leads to an increase in trypsin activity, which in turn stimulates PAR2 and PAR4 receptors, increases intestinal permeability, destroys the function of the intestinal barrier, and promotes the development of inflammatory processes