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Document clinical contraindication to semaglutide: Persistent nausea or vomiting preventing dose escalation beyond initial doses, a documented thyroid concern (e.g., personal or family history of MEN 2 or medullary thyroid carcinoma), or another clinically documented intolerance can serve as the basis for the exception request
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Even though obesity and other metabolic disorders are known to be higher in IBD patients, medications to treat obesity in this population are underutilized
Patients frequently experience improved insulin sensitivity, better glucose regulation, and decreased insulin resistance
One paper in March this year concluded that there was significant heterogeneity in the effects of GLP-1RAs across different cancer types. Theres some evidence they might protect against colorectal, prostate, and liver cancer, but may increase the risk of thyroid cancer
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