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Methods Pre-registration The study protocol and analysis plan were pre-registered on Open Science Framework ( Design Data were collected via the Smoking and Alcohol Toolkit Study, a monthly cross-sectional survey of a representative sample of adults ( 16 years) in Great Britain (i.e

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Furthermore, it was imperative that psychiatric medications and doses remained unchanged throughout the study period, and that no additional psychiatric medications (except for the study medication) were introduced during this period