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Green nanomaterials can be synthesized via biological or green routes using microorganisms such as bacteria, fungi, algae, and plant extracts, which act as reducing and stabilizing agents [110, 111]

Even though primary neurospheres derived from the DG of adult TrkB knockout mice and treated with BDNF displayed reduction in both number and size relative to those derived from the control mice, 46 the effect of BDNF on neurogenesis in vivo was not measured in the TrkB knockout mice