They are generally safe to take together, but it is best to consult with a healthcare provider before taking multiple supplements at once
An RCT of NAC, 600 mg per day, in pregnant women with a history of preterm birth and bacterial vaginosis showed that women receiving NAC had a lower rate of preterm birth and a higher gestational age at delivery, compared with placebo
Interestingly, however, this participants PHQ-9 score increased from 6 to 10: when individual items were examined, mood stayed the same with the change in score secondary to increased fatigue and change in appetite
(PubMed) Fernandez-Roig S, Lai SC, Murphy MM, Fernandez-Ballart J, Quadros EV
While more research is needed to confirm a direct connection in humans, these concerns have become part of the broader discussion in ongoing Ozempic lawsuits