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doi: 10.1007/s13577-017-0172-z 70 TanY.LinK.ZhaoY.WuQ.ChenD.WangJ.et al

Its antioxidant action helps slow down premature aging and reduces fatigue

Secondly, S100A8/A9 impaired T cell activation by inhibiting DCs MHC-II molecule expression and CD80/CD86 co-stimulatory molecules [92]

Notably, many of these non-motor symptoms appear years or even decades before the beginning of overt motor indications, indicating the possibility of serving as early prodromal biomarkers and mirroring the systemic, multisystemic aspect of PD pathogenesis [4]