semaglutide doesn't work for me Why Stopped Working: 5 Real Reasons & Fixes Why Compounded Semaglutide Isn't Working

When to Consider Alternatives Sometimes a different medication is the right answer: tirzepatide produces greater average weight loss

Most patients need a dose review with their provider every 4 weeks during titration

Last reviewed: June 18, 2026 Last updated: June 18, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

doi: 10.1016/j.pcad.2023.02.005

14-15 Therefore, a holistic approach that includes lifestyle modifications and medical supervision is necessary for sustainable weight management