Safer wording includes "supports firmer-looking skin," "helps improve the look of fine lines," "supports skin comfort," "helps maintain a healthy-looking barrier," "smooths the appearance of skin texture," and "supports mature-skin hydration." Avoid extreme medical claims such as "heals wounds," "treats scars," "repairs damaged tissue," or "regenerates skin," unless the product has the appropriate regulatory status and evidence for the target market
in fibroblast culture models it stimulates collagen, elastin, and glycosaminoglycan synthesis at picomolar to nanomolar concentrations (10 to 10 M), and modulates metalloproteinase (MMP-1, MMP-2, MMP-9) activity and their inhibitors (TIMP-1, TIMP-2), functioning as a general regulator of extracellular matrix remodeling ( Mechanistic research establishes that GHK activates TGF- and integrin 1 pathways during tissue repair, attracts immune and endothelial cells to wound sites, and restores gene expression patterns toward a healthier fibroblast phenotype in models of aging and radiation damage ( A 2018 review in IJMS characterizes its role in collagen production, nerve outgrowth stimulation, and dermal stem cell marker expression ( For Research Use Only
Its appeal lies in its regenerative capabilities without the negative side effects associated with NSAIDs or corticosteroids
Applying it topically is a completely different thing and has a clean track record
"Contributions of the brain angiotensin IV-AT4 receptor subtype system to spatial learning." J Neurosci 19(10): 3952-61
