Cagrilintide improves stability and pharmacokinetics of native amylin, extending the elimination half-life to approximately 168192 hours (roughly 7 days) in pharmacokinetic studies, which supports administration via a once-weekly injection protocol in clinical trial designs
MMADHC then transports cobalamin (II) bound to MMACHC to the MeSe enzyme in the cytosol and MMUT in the mitochondria
doi: 10.1136/jitc-2022-006516
Large-scale deletion and point mutations of the nuclear NDUFV1 and NDUFS1 genes in mitochondrial complex I deficiency
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