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Sometimes people need a routine and monthly might not be routine enough. Spratt said she would likely prefer to start a patient on a weekly injection first, and then transition them to a monthly injection if they tolerate the side effects well and successfully stick with the routine

These are particularly problematic for fatty liver because they can increase liver fat production

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Crucially, despite this variability, subsequent meta-analyses pooling the data from injectable GLP-1RAs have demonstrated a significant overall reduction in the risk of hospitalisation for HF with GLP-1RAs