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Designing GLP-1 delivery: structural perspectives and formulation approaches for optimized therapy

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Here, we provide an overview of the effect of GLP-1 RAs on ophthalmic diseases

And in short that came out a few years after that STEP 1 trial what we did for the very first time is take individuals with obesity and pre-existing cardiovascular disease, like a prior stroke, prior heart attack, or peripheral arterial disease, called PAD, and they're on maximal therapy for their cardiovascular disease or stroke, and then randomized them on top of that to either semaglutide or placebo

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