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Methods and materials Reagents Pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419) was synthesized by Kelowna International Scientific Inc

GHK-Cu, short for Gly-His-Lys-Copper, is a small peptide naturally present in the human body

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 40% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof